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Crystal structure of peroxisome proliferator-activated receptor gamma (pparg) in complex with tetrac

Analyse Crystal structure of peroxisome proliferator-activated receptor gamma (pparg)… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6TSG
Type: protein
Length: 258 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Peroxisome proliferator-activated receptor gamma
UniProt: P37231
Ligands: T4A
Pockets: 3 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 69% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Peroxisome proliferator-activated receptor gamma	protein	258	69% helix, 5% strand	P37231

Ligands and binding sites

T4A · 3,3',5,5'-tetraiodothyroacetic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	412	0.76	0.85	46	T4A
2	109	0.44	0.78	15	empty
3	50	0.26	0.73	13	empty

Compared structures

6TSG · Crystal structure of Peroxisome proliferator-activated receptor gamma (PPARG) in complex… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P37231
Elsewhere: RCSB PDB 6TSG · PDBe 6TSG · UniProt P37231

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