Research workbench
Crystal structure of the N-terminal half of the tfiih subunit P52
Analyse Crystal structure of the N-terminal half of the tfiih subunit P52 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6TRU
- Type
- protein
- Length
- 1,082 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA polymerase II transcription factor B subunit 2
- UniProt
- G0S965
- Pockets
- 20 · best druggability 0.73
Structure
x-ray diffraction · 4 distinct chains · 58% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | RNA polymerase II transcription factor B subunit 2 | protein | 280 | 57% helix, 7% strand | G0S965 |
| A | RNA polymerase II transcription factor B subunit 2 | protein | 275 | 56% helix, 7% strand | G0S965 |
| C | RNA polymerase II transcription factor B subunit 2 | protein | 263 | 59% helix, 5% strand | G0S965 |
| D | RNA polymerase II transcription factor B subunit 2 | protein | 264 | 59% helix, 6% strand | G0S965 |
Pockets
20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 225 | 0.73 | 0.88 | 47 | empty |
| 2 | 480 | 0.71 | 0.80 | 51 | empty |
| 3 | 109 | 0.66 | 0.89 | 24 | empty |
| 4 | 182 | 0.66 | 0.85 | 40 | empty |
| 5 | 144 | 0.63 | 0.85 | 32 | empty |
Interfaces
5 interfaces between chains.
- B–A · 1308 Ų buried · 7 hydrogen bonds · protein-protein
- C–D · 1141 Ų buried · 7 hydrogen bonds · protein-protein
- A–C · 368 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 262 Ų buried · 5 hydrogen bonds · protein-protein
- A–D · 151 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6TRU · Crystal structure of the N-terminal half of the TFIIH subunit p52 · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0S965
- Elsewhere: RCSB PDB 6TRU · PDBe 6TRU · UniProt G0S965
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.