Research workbench

Alcohol dehydrogenase from candida magnoliae dsmz 70638 (adha)

Analyse Alcohol dehydrogenase from candida magnoliae dsmz 70638 (adha) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6TQ3
Type: protein
Length: 954 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Enzyme subunit
Pockets: 13 · best druggability 0.86

Structure

x-ray diffraction · 2 distinct chains · 43% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, D	Enzyme subunit	protein	240	43% helix, 17% strand	—
C	Enzyme subunit	protein	234	44% helix, 18% strand	—

Pockets

13 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1074	0.86	0.87	65	empty
2	327	0.76	0.87	43	empty
3	303	0.75	0.87	47	empty
4	346	0.73	0.85	42	empty
5	346	0.65	0.79	42	empty

Interfaces

6 interfaces between chains.

C–D · 1607 Å² buried · 14 hydrogen bonds · protein-protein
A–B · 1571 Å² buried · 18 hydrogen bonds · protein-protein
A–C · 1211 Å² buried · 15 hydrogen bonds · protein-protein
B–D · 1203 Å² buried · 17 hydrogen bonds · protein-protein
A–D · 217 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

6TQ3 · Alcohol dehydrogenase from Candida magnoliae DSMZ 70638 (ADHA) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6TQ3 · PDBe 6TQ3

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