Research workbench

Crystal structure of human BCL6 btb domain in complex with compound 5

Analyse Crystal structure of human BCL6 btb domain in complex with compound 5 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6TOG
Type: protein
Length: 129 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: B-cell lymphoma 6 protein; Ala-TRP-val-ile-pro-ala
UniProt: P41182
Ligands: NQH, CL

Structure

x-ray diffraction · 2 distinct chains · 52% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	B-cell lymphoma 6 protein	protein	124	54% helix, 11% strand	P41182
B	Ala-TRP-val-ile-pro-ala	protein	5	0% helix, 20% strand	—

Ligands and binding sites

NQH · 2-chloranyl-4-(cyclopropylmethylamino)pyridine-3-carbonitrile · ligand · chains A
CL · Chloride ion · ion · chains A
DMS · Dimethyl sulfoxide · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 287 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

6TOG · Crystal structure of human BCL6 BTB domain in complex with compound 5 · the same entry in another collection · chain A against A, TM-score 1.00
P41182 · AlphaFold monomer V2.0 prediction for B-cell lymphoma 6 protein (P41182) · a predicted model of the same protein · chain A against A, TM-score 0.31

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P41182
Elsewhere: RCSB PDB 6TOG · PDBe 6TOG · UniProt P41182

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.