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Crystal structure of the human arc N-lobe bound to stargazin

Analyse Crystal structure of the human arc N-lobe bound to stargazin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6TNO
Type: protein
Length: 223 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ARC_C domain-containing protein; Chains: B,D,F
UniProt: A0A2I2UQ80
Pockets: 1 · best druggability 0.53

Structure

x-ray diffraction · 3 distinct chains · 62% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C, E	ARC_C domain-containing protein	protein	67	76% helix, 7% strand	A0A2I2UQ80
B, D	Chains: B,D,F	protein	7	0% helix, 57% strand	—
F	Chains: B,D,F	protein	8	0% helix, 50% strand	—

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	148	0.53	0.80	23	empty

Interfaces

7 interfaces between chains.

E–F · 772 Å² buried · 13 hydrogen bonds · protein-protein
A–B · 693 Å² buried · 11 hydrogen bonds · protein-protein
C–D · 688 Å² buried · 15 hydrogen bonds · protein-protein
A–E · 428 Å² buried · 10 hydrogen bonds · protein-protein
A–C · 421 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

6TNO · Crystal structure of the human Arc N-lobe bound to stargazin · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A2I2UQ80
Elsewhere: RCSB PDB 6TNO · PDBe 6TNO · UniProt A0A2I2UQ80

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