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Cryo-EM structure of toxoplasma gondii mitochondrial ATP synthase dimer, OSCP/F1/C-ring model

Analyse Cryo-EM structure of toxoplasma gondii mitochondrial ATP synthase dimer… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
6TMH
Type
protein
Length
4,264 residues
Chains
21
Method
electron microscopy
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt
A0A125YJP2, S7UU80, A0A125YYY4, A0A125YUH0, A0A125YRE2, S7VV10, A0A125YKF8, A0A125YJV2
Ligands
ATP, ADP, MG

Structure

electron microscopy · 11 distinct chains.

ChainMoleculeTypeResiduesSecondary structureUniProt
i—protein40—A0A125YJP2
A—protein512—S7UU80
E—protein507—S7UU80
C—protein487—S7UU80
B—protein479—A0A125YYY4
F, D—protein475—A0A125YYY4
g—protein272—A0A125YUH0
d—protein143—A0A125YRE2
e—protein65—S7VV10
G—protein99—A0A125YKF8
H, I, J, K, L, M, N, O, P, Q—protein71—A0A125YJV2

Ligands and binding sites

  • ATP · Adenosine-5'-triphosphate · ligand · 3 copies · chains A, B, E, F, C, D
  • ADP · Adenosine-5'-diphosphate · ligand · 2 copies · chains C, B, D
  • MG · Magnesium ion · metal · 5 copies · chains A, E, C, B, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

  • 6TMH · Cryo-EM structure of Toxoplasma gondii mitochondrial ATP synthase dimer, OSCP/F1/c-ring… · the same entry in another collection · chain i against i, TM-score 1.00

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