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Structural insights into pseudomonas aeruginosa type six secretion system exported effector 8: TSE8 in complex with a peptide

Analyse Structural insights into pseudomonas aeruginosa type six secretion system… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6TE4
Type: protein
Length: 1,135 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: TSE8; Pro-pro-leu-ala-ser-lys
UniProt: Q9HWL8
Pockets: 6 · best druggability 0.78

Structure

x-ray diffraction · 3 distinct chains · 38% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	TSE8	protein	564	38% helix, 13% strand	Q9HWL8
B	TSE8	protein	565	38% helix, 13% strand	Q9HWL8
C	Pro-pro-leu-ala-ser-lys	protein	6	0% helix, 0% strand	—

Pockets

6 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	572	0.78	0.84	54	empty
2	881	0.76	0.79	90	empty
3	117	0.71	0.92	37	empty
4	76	0.63	0.91	22	empty
5	106	0.54	0.83	20	empty

Interfaces

2 interfaces between chains.

A–C · 564 Å² buried · 2 hydrogen bonds · protein-protein
A–B · 474 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

6TE4 · Structural insights into Pseudomonas aeruginosa Type six secretion system exported… · the same entry in another collection · chain A against A, TM-score 1.00

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Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9HWL8
Elsewhere: RCSB PDB 6TE4 · PDBe 6TE4 · UniProt Q9HWL8

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