Research workbench
Leishmania tarentolae proteasome 20S subunit complexed with LXE408 and bortezomib
Analyse Leishmania tarentolae proteasome 20S subunit complexed with LXE408 and… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6TD5
- Type
- protein
- Length
- 6,360 residues
- Chains
- 28
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Ligands
- BO2, N2E
Structure
electron microscopy · 14 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, a | — | protein | 245 | — | — |
| B, b | — | protein | 229 | — | — |
| C, c | — | protein | 272 | — | — |
| D, d | — | protein | 240 | — | — |
| E, e | — | protein | 235 | — | — |
| F, f | — | protein | 238 | — | — |
| G, g | — | protein | 230 | — | — |
| H, h | — | protein | 229 | — | — |
| I, i | — | protein | 219 | — | — |
| J, j | — | protein | 204 | — | — |
| K, k | — | protein | 206 | — | — |
| L, l | — | protein | 201 | — | — |
| M, m | — | protein | 214 | — | — |
| N, n | — | protein | 218 | — | — |
Ligands and binding sites
- BO2 · N-[(1R)-1-(dihydroxyboryl)-3-methylbutyl]-N-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide · ligand · 6 copies · chains H, I, L, M, h, i, l, m
- N2E · ~{N}-[4-fluoranyl-3-[6-(3-methylpyridin-2-yl)-[1,2, 4]triazolo[1,5-a]pyrimidin-2-yl]phenyl]-2,4-dimethyl-1,3-oxazole-5-carboxamide · ligand · 2 copies · chains K, L, k, l
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6TD5 · Leishmania tarentolae proteasome 20S subunit complexed with LXE408 and bortezomib · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6TD5 · PDBe 6TD5
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