Research workbench
Crystal structure of CIAO1-CIAO2B cia core complex
Analyse Crystal structure of CIAO1-CIAO2B cia core complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6TBN
- Type
- protein
- Length
- 479 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MIP18 family protein galla-2; Probable cytosolic iron-sulfur protein assembly protein…
- UniProt
- Q9VTC4, Q7K1Y4
- Ligands
- NA
- Pockets
- 5 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 13% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | MIP18 family protein galla-2 | protein | 143 | 42% helix, 13% strand | Q9VTC4 |
| B | Probable cytosolic iron-sulfur protein assembly protein CIAO1 | protein | 336 | 0% helix, 56% strand | Q7K1Y4 |
Ligands and binding sites
- NA · Sodium ion · metal · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 503 | 0.77 | 0.85 | 36 | empty |
| 2 | 412 | 0.70 | 0.82 | 48 | empty |
| 3 | 105 | 0.41 | 0.77 | 15 | empty |
| 4 | 50 | 0.38 | 0.81 | 13 | empty |
| 5 | 91 | 0.31 | 0.73 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1082 Ų buried · 24 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (oxidation).
Compared structures
- 6TBN · Crystal structure of CIAO1-CIAO2B CIA core complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q7K1Y4 · AlphaFold monomer V2.0 prediction for probable cytosolic iron-sulfur protein assembly… · a predicted model of the same protein · chain B against A, TM-score 0.99
- Q9VTC4 · AlphaFold monomer V2.0 prediction for MIP18 family protein galla-2 (Q9VTC4) · a predicted model of the same protein · chain A against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9VTC4
- Every structure of UniProt Q7K1Y4
- Elsewhere: RCSB PDB 6TBN · PDBe 6TBN · UniProt Q9VTC4 · UniProt Q7K1Y4
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