Research workbench
Crystal structure of MMS19(CTD)-CIAO1-CIAO2B cia targeting complex
Analyse Crystal structure of MMS19(CTD)-CIAO1-CIAO2B cia targeting complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6TBL
- Type
- protein
- Length
- 1,210 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MMS19 nucleotide excision repair protein homolog; MIP18 family protein galla-2; Probable…
- UniProt
- Q9D071, Q9VTC4, Q7K1Y4
- Ligands
- K
- Pockets
- 14 · best druggability 0.78
Structure
x-ray diffraction · 6 distinct chains · 26% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | MMS19 nucleotide excision repair protein homolog | protein | 119 | 75% helix, 0% strand | Q9D071 |
| B | MMS19 nucleotide excision repair protein homolog | protein | 120 | 77% helix, 0% strand | Q9D071 |
| C | MIP18 family protein galla-2 | protein | 150 | 43% helix, 12% strand | Q9VTC4 |
| D | MIP18 family protein galla-2 | protein | 151 | 43% helix, 12% strand | Q9VTC4 |
| E | Probable cytosolic iron-sulfur protein assembly protein CIAO1 | protein | 334 | 0% helix, 53% strand | Q7K1Y4 |
| F | Probable cytosolic iron-sulfur protein assembly protein CIAO1 | protein | 336 | 0% helix, 53% strand | Q7K1Y4 |
Ligands and binding sites
- K · Potassium ion · metal · 2 copies · chains A, B
- EDO · 1,2-ethanediol · additive · 3 copies · chains C, E, D, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
14 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 979 | 0.78 | 0.80 | 61 | empty |
| 2 | 463 | 0.78 | 0.86 | 37 | empty |
| 3 | 1199 | 0.77 | 0.79 | 82 | empty |
| 4 | 408 | 0.75 | 0.85 | 37 | empty |
| 5 | 209 | 0.56 | 0.79 | 29 | empty |
Interfaces
7 interfaces between chains.
- D–F · 1031 Ų buried · 20 hydrogen bonds · protein-protein
- C–E · 978 Ų buried · 19 hydrogen bonds · protein-protein
- A–C · 827 Ų buried · 12 hydrogen bonds · protein-protein
- B–D · 801 Ų buried · 11 hydrogen bonds · protein-protein
- A–F · 188 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 6TBL · Crystal structure of MMS19(CTD)-CIAO1-CIAO2B CIA targeting complex · the same entry in another collection · chain F against F, TM-score 1.00
- Q7K1Y4 · AlphaFold monomer V2.0 prediction for probable cytosolic iron-sulfur protein assembly… · a predicted model of the same protein · chain E against A, TM-score 0.99
- Q9D071 · AlphaFold monomer V2.0 prediction for MMS19 nucleotide excision repair protein homolog… · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q9VTC4 · AlphaFold monomer V2.0 prediction for MIP18 family protein galla-2 (Q9VTC4) · a predicted model of the same protein · chain C against A, TM-score 0.84
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9D071
- Every structure of UniProt Q9VTC4
- Every structure of UniProt Q7K1Y4
- Elsewhere: RCSB PDB 6TBL · PDBe 6TBL · UniProt Q9D071 · UniProt Q9VTC4 · UniProt Q7K1Y4
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