Research workbench
Myo-1 from myroides odoratimimus. environmental metallo-beta- lactamases exhibit high enzymatic activity under zinc deprivation
Analyse Myo-1 from myroides odoratimimus. environmental metallo-beta- lactamases… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6T5L
- Type
- protein
- Length
- 432 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Subclass B1 metallo-beta-lactamase
- UniProt
- A0A0U3H0V9
- Ligands
- ZN, MG
- Pockets
- 3 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 23% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Subclass B1 metallo-beta-lactamase | protein | 224 | 25% helix, 32% strand | A0A0U3H0V9 |
| B | Subclass B1 metallo-beta-lactamase | protein | 208 | 20% helix, 32% strand | A0A0U3H0V9 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 659 | 0.68 | 0.77 | 59 | empty |
| 2 | 146 | 0.67 | 0.87 | 28 | empty |
| 3 | 61 | 0.31 | 0.76 | 18 | ZN |
Interfaces
1 interface between chains.
- A–B · 710 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6T5L · MYO-1 from Myroides odoratimimus. Environmental metallo-beta-lactamases exhibit high… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0U3H0V9
- Elsewhere: RCSB PDB 6T5L · PDBe 6T5L · UniProt A0A0U3H0V9
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