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Moxr aaa-ATPase rava, C2-symmetric closed ring conformation

Analyse Moxr aaa-ATPase rava, C2-symmetric closed ring conformation in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6SZA
Type: protein
Length: 2,886 residues
Chains: 6
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Rava
UniProt: P31473
Ligands: ADP
Pockets: 20 · best druggability 0.81

Structure

electron microscopy · 1 distinct chain · 41% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, A, D, F, E, C	Rava	protein	481	41% helix, 14% strand	P31473

Ligands and binding sites

ADP · Adenosine-5'-diphosphate · ligand · 4 copies · chains B, C, A, D, E, F

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	938	0.81	0.83	94	ADP
2	898	0.80	0.83	88	ADP
3	738	0.80	0.84	73	ADP
4	947	0.80	0.82	91	ADP
5	1003	0.75	0.78	108	empty

Interfaces

6 interfaces between chains.

D–E · 1643 Å² buried · 19 hydrogen bonds · protein-protein
B–C · 1605 Å² buried · 20 hydrogen bonds · protein-protein
B–A · 1602 Å² buried · 18 hydrogen bonds · protein-protein
F–E · 1600 Å² buried · 17 hydrogen bonds · protein-protein
A–F · 1222 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

6SZA · MoxR AAA-ATPase RavA, C2-symmetric closed ring conformation · the same entry in another collection · chain D against D, TM-score 1.00
P31473 · AlphaFold monomer V2.0 prediction for ATPase rava (P31473) · a predicted model of the same protein · chain B against A, TM-score 0.82

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P31473
Elsewhere: RCSB PDB 6SZA · PDBe 6SZA · UniProt P31473

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