Research workbench
Chaetomium thermophilum beta-glucosidase
Analyse Chaetomium thermophilum beta-glucosidase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6SZ6
- Type
- protein
- Length
- 836 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beta-glucosidase
- UniProt
- A6YRT4
- Ligands
- NAG, BMA, MAN, BGC
- Pockets
- 11 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 25% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Beta-glucosidase | protein | 836 | 25% helix, 20% strand | A6YRT4 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 16 copies · chains A
- BMA · beta-D-mannopyranose · sugar · 6 copies · chains A
- MAN · alpha-D-mannopyranose · sugar · 5 copies · chains A
- BGC · beta-D-glucopyranose · sugar · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 192 | 0.69 | 0.87 | 39 | empty |
| 2 | 62 | 0.62 | 0.92 | 20 | empty |
| 3 | 196 | 0.59 | 0.81 | 31 | BGC |
| 4 | 147 | 0.53 | 0.80 | 19 | NAG |
| 5 | 173 | 0.51 | 0.78 | 21 | empty |
Modifications
Observed in the structure: 7 glycan, 3 disulfide (N-glycosylation, disulfide).
Compared structures
- 6SZ6 · Chaetomium thermophilum beta-glucosidase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A6YRT4
- Elsewhere: RCSB PDB 6SZ6 · PDBe 6SZ6 · UniProt A6YRT4
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