Research workbench
The dbb dimerization domain of B-cell adaptor for PI3K (bcap) is required for down regulation of inflammatory signalling through the toll-like receptor pathway
Analyse The dbb dimerization domain of B-cell adaptor for PI3K (bcap) is required for… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6SWS
- Type
- protein
- Length
- 543 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphoinositide 3-kinase adapter protein 1
- UniProt
- Q6ZUJ8
- Pockets
- 3 · best druggability 0.57
Structure
x-ray diffraction · 4 distinct chains · 13% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphoinositide 3-kinase adapter protein 1 | protein | 113 | 15% helix, 47% strand | Q6ZUJ8 |
| B, D | Phosphoinositide 3-kinase adapter protein 1 | protein | 112 | 14% helix, 46% strand | Q6ZUJ8 |
| C | Phosphoinositide 3-kinase adapter protein 1 | protein | 109 | 13% helix, 48% strand | Q6ZUJ8 |
| E | Phosphoinositide 3-kinase adapter protein 1 | protein | 97 | 9% helix, 49% strand | Q6ZUJ8 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 337 | 0.57 | 0.76 | 28 | empty |
| 2 | 83 | 0.50 | 0.83 | 28 | empty |
| 3 | 52 | 0.26 | 0.74 | 14 | empty |
Interfaces
6 interfaces between chains.
- A–B · 983 Ų buried · 2 hydrogen bonds · protein-protein
- B–E · 626 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 624 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 421 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 169 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6SWS · The DBB dimerization domain of B-cell adaptor for PI3K (BCAP) is required for down… · the same entry in another collection · chain E against E, TM-score 1.00
- Q6ZUJ8 · AlphaFold monomer V2.0 prediction for phosphoinositide 3-kinase adapter protein 1 (Q6ZUJ8) · a predicted model of the same protein · chain E against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6ZUJ8
- Elsewhere: RCSB PDB 6SWS · PDBe 6SWS · UniProt Q6ZUJ8
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