Research workbench
Crystal structure of crebbp bromodomain L1109W mutant
Analyse Crystal structure of crebbp bromodomain L1109W mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6SW3
- Type
- protein
- Length
- 233 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cdna FLJ57039, highly similar to creb-binding protein
- UniProt
- B4E3L4
- Pockets
- 3 · best druggability 0.48
Structure
x-ray diffraction · 2 distinct chains · 63% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cdna FLJ57039, highly similar to creb-binding protein | protein | 115 | 63% helix, 0% strand | B4E3L4 |
| B | Cdna FLJ57039, highly similar to creb-binding protein | protein | 118 | 62% helix, 0% strand | B4E3L4 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 87 | 0.48 | 0.81 | 20 | empty |
| 2 | 77 | 0.45 | 0.81 | 20 | empty |
| 3 | 87 | 0.34 | 0.74 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 127 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 6SW3 · Crystal structure of CREBBP bromodomain L1109W mutant · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B4E3L4
- Elsewhere: RCSB PDB 6SW3 · PDBe 6SW3 · UniProt B4E3L4
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