Research workbench
Selective affimers recognize BCL-2 family proteins through non- canonical structural motifs
Analyse Selective affimers recognize BCL-2 family proteins through non- canonical… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6STJ
- Type
- protein
- Length
- 875 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Induced myeloid leukemia cell differentiation protein mcl- 1; Cystatin domain-containing…
- UniProt
- Q07820
- Pockets
- 12 · best druggability 0.83
Structure
x-ray diffraction · 7 distinct chains · 61% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Induced myeloid leukemia cell differentiation protein mcl- 1 | protein | 141 | 82% helix, 1% strand | Q07820 |
| B | Induced myeloid leukemia cell differentiation protein mcl- 1 | protein | 142 | 82% helix, 1% strand | Q07820 |
| C | Induced myeloid leukemia cell differentiation protein mcl- 1 | protein | 103 | 80% helix, 0% strand | Q07820 |
| D | Induced myeloid leukemia cell differentiation protein mcl- 1 | protein | 134 | 84% helix, 0% strand | Q07820 |
| E | Cystatin domain-containing protein | protein | 89 | 20% helix, 55% strand | — |
| F | Cystatin domain-containing protein | protein | 90 | 21% helix, 54% strand | — |
| G, H | Cystatin domain-containing protein | protein | 88 | 23% helix, 58% strand | — |
Pockets
12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 716 | 0.83 | 0.87 | 66 | empty |
| 2 | 413 | 0.80 | 0.88 | 41 | empty |
| 3 | 464 | 0.80 | 0.87 | 48 | empty |
| 4 | 166 | 0.65 | 0.85 | 18 | empty |
| 5 | 61 | 0.50 | 0.85 | 14 | empty |
Interfaces
21 interfaces between chains.
- A–E · 892 Ų buried · 12 hydrogen bonds · protein-protein
- B–F · 887 Ų buried · 13 hydrogen bonds · protein-protein
- D–H · 638 Ų buried · 8 hydrogen bonds · protein-protein
- C–G · 610 Ų buried · 9 hydrogen bonds · protein-protein
- B–H · 524 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6STJ · Selective Affimers Recognize BCL-2 Family Proteins Through Non-Canonical Structural Motifs · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q07820
- Elsewhere: RCSB PDB 6STJ · PDBe 6STJ · UniProt Q07820
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.