Research workbench

Unliganded glutaminyl-tRNA synthetase

Analyse Unliganded glutaminyl-tRNA synthetase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1NYL
Type: protein
Length: 523 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glutaminyl-tRNA synthetase
EC: 6.1.1.18
UniProt: P00962
Pockets: 5 · best druggability 0.66

Structure

x-ray diffraction · 1 distinct chain · 29% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glutaminyl-tRNA synthetase (EC 6.1.1.18)	protein	523	29% helix, 22% strand	P00962

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	143	0.66	0.87	28	empty
2	284	0.60	0.79	33	empty
3	116	0.42	0.77	19	empty
4	73	0.35	0.76	22	empty
5	77	0.33	0.75	19	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

1NYL · Unliganded glutaminyl-tRNA synthetase · the same entry in another collection · chain A against A, TM-score 1.00
P00962 · AlphaFold monomer V2.0 prediction for glutamine--tRNA ligase (P00962) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00962
Elsewhere: RCSB PDB 1NYL · PDBe 1NYL · UniProt P00962

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