Research workbench
Structure of the fanconi anaemia core complex
Analyse Structure of the fanconi anaemia core complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6SRI
- Type
- protein
- Length
- 3,827 residues
- Chains
- 47
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Unassigned secondary structure elements (central region, proposed fancb-FAAP100: chain…
- UniProt
- Q3MUH5
- Pockets
- 20 · best druggability 0.69
Structure
electron microscopy · 28 distinct chains · 41% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, a, 3 | Unassigned secondary structure elements (central region, proposed fancb-FAAP100: chain A,A | protein | 76 | 32% helix, 0% strand | — |
| B, b | Unassigned secondary structure elements (central region, proposed fancb-FAAP100) | protein | 25 | 12% helix, 4% strand | — |
| C, c | Unassigned secondary structure elements (central region, proposed fancb-FAAP100) | protein | 30 | 0% helix, 7% strand | — |
| D, d | Unassigned secondary structure elements (central region, proposed fancb-FAAP100) | protein | 23 | 0% helix, 4% strand | — |
| E, e | Unassigned secondary structure elements (central region, proposed fancb-FAAP100) | protein | 9 | 0% helix, 0% strand | — |
| F, f, Z | Unassigned secondary structure elements (central region, proposed fancb-FAAP100: chain F,F | protein | 15 | 0% helix, 0% strand | — |
| G, g | Unassigned secondary structure elements (central region, proposed fancb-FAAP100) | protein | 26 | 0% helix, 0% strand | — |
| H, J, h, j | Unassigned secondary structure elements (central region, proposed fancb-FAAP100) | protein | 17 | 47% helix, 0% strand | — |
| I, i | Unassigned secondary structure elements (central region, proposed fancb-FAAP100) | protein | 37 | 73% helix, 0% strand | — |
| K, k | Unassigned secondary structure elements (central region, proposed fancb-FAAP100) | protein | 21 | 90% helix, 0% strand | — |
| L, l | Unassigned secondary structure elements (central region, proposed fancb-FAAP100) | protein | 18 | 89% helix, 0% strand | — |
| M, m | Unassigned secondary structure elements (proposed fancb) | protein | 120 | 33% helix, 3% strand | — |
| N, n | Unassigned secondary structure elements (proposed FAAP100) | protein | 43 | 95% helix, 0% strand | — |
| o, O | Unassigned secondary structure elements (proposed fancb) | protein | 279 | 1% helix, 8% strand | — |
| p, P | Unassigned secondary structure elements (proposed FAAP100) | protein | 276 | 0% helix, 8% strand | — |
| U | Unassigned secondary structure elements (base region, proposed fancc-fanc-E-fancf) | protein | 227 | 70% helix, 0% strand | — |
| V | Unassigned secondary structure elements (base region, proposed fancc-fanc-E-fancf) | protein | 27 | 81% helix, 0% strand | — |
| W | Unassigned secondary structure elements (base region, proposed fancc-fanc-E-fancf) | protein | 20 | 80% helix, 0% strand | — |
| X | Unassigned secondary structure elements (base region, proposed fancc-fanc-E-fancf) | protein | 13 | 69% helix, 0% strand | — |
| Y | Unassigned secondary structure elements (base region, proposed fancc-fanc-E-fancf) | protein | 84 | 62% helix, 0% strand | — |
| 1 | Unassigned secondary structure elements (base region, proposed fancc-fanc-E-fancf) | protein | 109 | 73% helix, 0% strand | — |
| 2 | Unassigned secondary structure elements (base region, proposed fancc-fanc-E-fancf) | protein | 62 | 63% helix, 0% strand | — |
| 4 | Unassigned secondary structure elements (base region, proposed fancc-fanc-E-fancf) | protein | 71 | 52% helix, 0% strand | — |
| q | Fanconi anaemia protein fancl | protein | 337 | 22% helix, 1% strand | Q3MUH5 |
| T | Base region, proposed fancf | protein | 201 | 65% helix, 1% strand | — |
| R | Unassigned secondary structure elements (top region, proposed fancg) | protein | 285 | 63% helix, 0% strand | — |
| S | Unassigned secondary structure elements (top region, proposed fancg) | protein | 145 | 65% helix, 0% strand | — |
| Q | Fanconi anaemia protein fancl | protein | 91 | 18% helix, 2% strand | Q3MUH5 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 930 | 0.69 | 0.75 | 109 | empty |
| 2 | 855 | 0.68 | 0.75 | 101 | empty |
| 3 | 821 | 0.66 | 0.75 | 84 | empty |
| 4 | 501 | 0.63 | 0.77 | 54 | empty |
| 5 | 466 | 0.63 | 0.77 | 51 | empty |
Interfaces
60 interfaces between chains.
- M–m · 712 Ų buried · 19 hydrogen bonds · protein-protein
- b–c · 374 Ų buried · 3 hydrogen bonds · protein-protein
- B–C · 373 Ų buried · 3 hydrogen bonds · protein-protein
- E–F · 251 Ų buried · 7 hydrogen bonds · protein-protein
- b–d · 250 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 6SRI · Structure of the Fanconi anaemia core complex · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q3MUH5
- Elsewhere: RCSB PDB 6SRI · PDBe 6SRI · UniProt Q3MUH5
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