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Crystal structure of the rac core with a pseudo substrate bound to SSZ1 sbd

Analyse Crystal structure of the rac core with a pseudo substrate bound to SSZ1 sbd in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6SR6
Type: protein
Length: 1,149 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative heat shock protein; Putative ribosome associated protein
UniProt: G0RZX9, G0RYD6
Ligands: ATP, MG
Pockets: 14 · best druggability 0.80

Structure

x-ray diffraction · 4 distinct chains · 32% helix, 36% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Putative heat shock protein	protein	519	32% helix, 36% strand	G0RZX9
B	Putative ribosome associated protein	protein	52	25% helix, 31% strand	G0RYD6
C	Putative heat shock protein	protein	524	31% helix, 36% strand	G0RZX9
D	Putative ribosome associated protein	protein	54	30% helix, 30% strand	G0RYD6

Ligands and binding sites

ATP · Adenosine-5'-triphosphate · ligand · 2 copies · chains A, C
MG · Magnesium ion · metal · 2 copies · chains A, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

14 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	512	0.80	0.87	64	ATP, MG
2	607	0.79	0.85	72	ATP, MG
3	362	0.63	0.79	37	empty
4	341	0.55	0.75	46	empty
5	263	0.54	0.76	24	empty

Interfaces

3 interfaces between chains.

C–D · 2733 Å² buried · 39 hydrogen bonds · protein-protein
A–B · 2659 Å² buried · 43 hydrogen bonds · protein-protein
A–C · 422 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

6SR6 · Crystal structure of the RAC core with a pseudo substrate bound to Ssz1 SBD · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G0RZX9
Every structure of UniProt G0RYD6
Elsewhere: RCSB PDB 6SR6 · PDBe 6SR6 · UniProt G0RZX9 · UniProt G0RYD6

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