Research workbench
Mouse interleukin-12 subunit beta - P80 homodimer in space group P21 crystal form 1
Analyse Mouse interleukin-12 subunit beta - P80 homodimer in space group P21 crystal… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6SP3
- Type
- protein
- Length
- 603 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interleukin-12 subunit beta
- UniProt
- P43432
- Ligands
- MAN, NAG, BMA, CL
- Pockets
- 2 · best druggability 0.60
Structure
x-ray diffraction · 2 distinct chains · 2% helix, 54% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interleukin-12 subunit beta | protein | 301 | 2% helix, 54% strand | P43432 |
| B | Interleukin-12 subunit beta | protein | 302 | 2% helix, 54% strand | P43432 |
Ligands and binding sites
- MAN · alpha-D-mannopyranose · sugar · 6 copies · chains A, B
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains A, B
- BMA · beta-D-mannopyranose · sugar · 2 copies · chains A, B
- CL · Chloride ion · ion · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 297 | 0.60 | 0.78 | 36 | empty |
| 2 | 194 | 0.51 | 0.77 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 331 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 13 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
- 6SP3 · mouse Interleukin-12 subunit beta - p80 homodimer in space group P21 crystal form 1 · the same entry in another collection · chain B against B, TM-score 1.00
- P43432 · AlphaFold monomer V2.0 prediction for interleukin-12 subunit beta (P43432) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43432
- Elsewhere: RCSB PDB 6SP3 · PDBe 6SP3 · UniProt P43432
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