Research workbench
The interacting head motif in insect flight muscle myosin thick filaments
Analyse The interacting head motif in insect flight muscle myosin thick filaments in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6SO3
- Type
- protein
- Length
- 2,384 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myosin 2 heavy chain striated muscle; Myosin 2 essential light chain striated muscle…
- Pockets
- 14 · best druggability 0.66
Structure
electron microscopy · 3 distinct chains · 38% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A | Myosin 2 heavy chain striated muscle | protein | 840 | 37% helix, 11% strand | — |
| D, C | Myosin 2 essential light chain striated muscle | protein | 156 | 50% helix, 6% strand | — |
| F, E | Myosin 2 regulatory light chain striated muscle | protein | 196 | 32% helix, 1% strand | — |
Pockets
14 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 67 | 0.66 | 0.93 | 21 | empty |
| 2 | 240 | 0.58 | 0.79 | 34 | empty |
| 3 | 250 | 0.54 | 0.77 | 23 | empty |
| 4 | 298 | 0.51 | 0.74 | 45 | empty |
| 5 | 78 | 0.48 | 0.82 | 18 | empty |
Interfaces
10 interfaces between chains.
- B–D · 3877 Ų buried · 37 hydrogen bonds · protein-protein
- A–C · 2975 Ų buried · 27 hydrogen bonds · protein-protein
- B–F · 2609 Ų buried · 40 hydrogen bonds · protein-protein
- A–E · 2276 Ų buried · 23 hydrogen bonds · protein-protein
- B–A · 1995 Ų buried · 33 hydrogen bonds · protein-protein
Compared structures
- 6SO3 · The interacting head motif in insect flight muscle myosin thick filaments · the same entry in another collection · chain F against F, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6SO3 · PDBe 6SO3
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