Research workbench
Structure of the TLE1 effector bound to the vgrg spike from the type 6 secretion system
Analyse Structure of the TLE1 effector bound to the vgrg spike from the type 6… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6SJL
- Type
- protein
- Length
- 2,537 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative type VI secretion protein
- UniProt
- A0A3W2RZ19, A0A377LA80
- Pockets
- 20 · best druggability 0.75
Structure
electron microscopy · 3 distinct chains · 27% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Putative type VI secretion protein | protein | 324 | 12% helix, 46% strand | A0A3W2RZ19 |
| D | Putative type VI secretion protein | protein | 521 | 31% helix, 24% strand | A0A377LA80 |
| E, F | Putative type VI secretion protein | protein | 522 | 32% helix, 24% strand | A0A377LA80 |
Pockets
20 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 469 | 0.75 | 0.83 | 52 | empty |
| 2 | 518 | 0.74 | 0.82 | 53 | empty |
| 3 | 512 | 0.74 | 0.82 | 55 | empty |
| 4 | 105 | 0.55 | 0.84 | 31 | empty |
| 5 | 103 | 0.50 | 0.82 | 23 | empty |
Interfaces
12 interfaces between chains.
- A–B · 7776 Ų buried · 207 hydrogen bonds · protein-protein
- B–C · 7776 Ų buried · 193 hydrogen bonds · protein-protein
- A–C · 7760 Ų buried · 204 hydrogen bonds · protein-protein
- A–D · 1761 Ų buried · 29 hydrogen bonds · protein-protein
- B–E · 1719 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 6SJL · Structure of the Tle1 effector bound to the VgrG spike from the Type 6 secretion system · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A3W2RZ19
- Every structure of UniProt A0A377LA80
- Elsewhere: RCSB PDB 6SJL · PDBe 6SJL · UniProt A0A3W2RZ19 · UniProt A0A377LA80
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