Research workbench
Proteasome accessory factor B/C (pafbc) of arthrobacter aurescens
Analyse Proteasome accessory factor B/C (pafbc) of arthrobacter aurescens in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6SJ9
- Type
- protein
- Length
- 1,279 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proteasome accessory factor B/C (pafbc)
- Ligands
- K, SCN
- Pockets
- 19 · best druggability 0.89
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Proteasome accessory factor B/C (pafbc) | protein | 642 | 37% helix, 25% strand | — |
| B | Proteasome accessory factor B/C (pafbc) | protein | 637 | 39% helix, 26% strand | — |
Ligands and binding sites
- K · Potassium ion · metal · 2 copies · chains A, B
- SCN · Thiocyanate ion · ion · 2 copies · chains A, B
- PEG · Di(hydroxyethyl)ether · additive · 4 copies · chains A, B
- PG4 · Tetraethylene glycol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
19 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1106 | 0.89 | 0.90 | 122 | empty |
| 2 | 976 | 0.88 | 0.90 | 98 | empty |
| 3 | 605 | 0.65 | 0.76 | 60 | empty |
| 4 | 298 | 0.65 | 0.81 | 29 | empty |
| 5 | 392 | 0.60 | 0.76 | 39 | empty |
Interfaces
1 interface between chains.
- A–B · 634 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 14 modified (engineered).
Compared structures
- 6SJ9 · Proteasome accessory factor B/C (PafBC) of Arthrobacter aurescens · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6SJ9 · PDBe 6SJ9
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