Research workbench
Transthyritin derived amyloid fibril from patient with hereditary V30M attr amyloidosis
Analyse Transthyritin derived amyloid fibril from patient with hereditary V30M attr… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6SDZ
- Type
- protein
- Length
- 1,012 residues
- Chains
- 11
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transthyretin
- UniProt
- P02766
- Pockets
- 4 · best druggability 0.86
Structure
electron microscopy · 1 distinct chain · 0% helix, 53% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K | Transthyretin | protein | 92 | 0% helix, 53% strand | P02766 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 843 | 0.86 | 0.89 | 99 | empty |
| 2 | 249 | 0.83 | 0.95 | 56 | empty |
| 3 | 267 | 0.80 | 0.92 | 62 | empty |
| 4 | 120 | 0.44 | 0.77 | 31 | empty |
Interfaces
19 interfaces between chains.
- E–F · 3894 Ų buried · 128 hydrogen bonds · protein-protein
- J–K · 3886 Ų buried · 141 hydrogen bonds · protein-protein
- B–C · 3878 Ų buried · 131 hydrogen bonds · protein-protein
- F–G · 3876 Ų buried · 130 hydrogen bonds · protein-protein
- A–B · 3871 Ų buried · 140 hydrogen bonds · protein-protein
Compared structures
- 6SDZ · transthyritin derived amyloid fibril from patient with hereditary V30M ATTR amyloidosis · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02766
- Elsewhere: RCSB PDB 6SDZ · PDBe 6SDZ · UniProt P02766
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.