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Structure of a type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate

Analyse Structure of a type III CRISPR defence DNA nuclease activated by cyclic… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6SCE
Type: protein + RNA
Length: 618 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Uncharacterized protein; Cyclic oligoadenylate
UniProt: Q53W14
Pockets: 6 · best druggability 0.83

Structure

x-ray diffraction · 2 distinct chains · 39% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Uncharacterized protein	protein	614	39% helix, 24% strand	Q53W14
B	Cyclic oligoadenylate	rna	4	—	—

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1005	0.83	0.84	77	empty
2	78	0.58	0.88	19	empty
3	66	0.37	0.78	13	empty
4	63	0.37	0.79	14	empty
5	70	0.32	0.75	19	empty

Interfaces

1 interface between chains.

A–B · 1058 Å² buried · 36 hydrogen bonds · protein-nucleic

Modifications

Observed in the structure: 7 modified (engineered).

Compared structures

6SCE · Structure of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q53W14
Elsewhere: RCSB PDB 6SCE · PDBe 6SCE · UniProt Q53W14

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