Research workbench

Ring-like darpin-armadillo fusion H83_D01

Analyse Ring-like darpin-armadillo fusion H83_D01 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6SA8
Type: protein
Length: 675 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ring-like darpin-armadillo fusion H83_D01; Lys-arg-lys-arg-lys-arg-lys-arg-lys-arg
Pockets: 2 · best druggability 0.53

Structure

x-ray diffraction · 2 distinct chains · 63% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ring-like darpin-armadillo fusion H83_D01	protein	665	64% helix, 0% strand	—
B	Lys-arg-lys-arg-lys-arg-lys-arg-lys-arg	protein	10	0% helix, 0% strand	—

Ligands and binding sites

EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	258	0.53	0.76	44	empty
2	65	0.34	0.76	14	empty

Interfaces

1 interface between chains.

A–B · 1218 Å² buried · 30 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

6SA8 · ring-like DARPin-Armadillo fusion H83_D01 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6SA8 · PDBe 6SA8

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