Research workbench
Fumarate hydratase of mycobacterium tuberculosis in complex with formate and allosteric modulator N-(5-((3,4-dihydroisoquinolin-2(1H)- YL)SULFONYL)-2-methoxyphenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl) acetamide
Analyse Fumarate hydratase of mycobacterium tuberculosis in complex with formate and… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6S7Z
- Type
- protein
- Length
- 1,804 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- A0A045IXZ8
- Ligands
- KZN, MG
Structure
x-ray diffraction · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | — | protein | 449 | — | A0A045IXZ8 |
| B | — | protein | 458 | — | A0A045IXZ8 |
| D | — | protein | 448 | — | A0A045IXZ8 |
Ligands and binding sites
- KZN · ~{N}-[5-(3,4-dihydro-1~{H}-isoquinolin-2-ylsulfonyl)-2-methoxy-phenyl]-2-(4-oxidanylidene-3~{H}-phthalazin-1-yl)ethanamide · ligand · 2 copies · chains A, C
- MG · Magnesium ion · metal · chains B
- FMT · Formic acid · additive · chains B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6S7Z · Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A045IXZ8
- Elsewhere: RCSB PDB 6S7Z · PDBe 6S7Z · UniProt A0A045IXZ8
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