Research workbench
Structure of the fluorescent protein AAUSFP1 from aequorea cf. australis at pH 7.0
Analyse Structure of the fluorescent protein AAUSFP1 from aequorea cf. australis at pH… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6S67
- Type
- protein
- Length
- 892 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Aequorea cf. australis fluorescent protein 1 (AAUSFP1)
- Ligands
- CRO
- Pockets
- 8 · best druggability 0.84
Structure
x-ray diffraction · 1 distinct chain · 8% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Aequorea cf. australis fluorescent protein 1 (AAUSFP1) | protein | 223 | 8% helix, 52% strand | — |
Ligands and binding sites
- CRO · {2-[(1R,2R)-1-amino-2-hydroxypropyl]-4-(4-hydroxybenzylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl}acetic acid · ligand · 4 copies · chains A, B, C, D
- GOL · Glycerol · additive · 5 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1058 | 0.84 | 0.85 | 111 | GOL |
| 2 | 92 | 0.78 | 0.98 | 26 | CRO |
| 3 | 92 | 0.77 | 0.98 | 24 | CRO |
| 4 | 93 | 0.77 | 0.98 | 25 | CRO |
| 5 | 92 | 0.77 | 0.98 | 29 | CRO |
Interfaces
6 interfaces between chains.
- A–B · 1291 Ų buried · 17 hydrogen bonds · protein-protein
- C–D · 1287 Ų buried · 17 hydrogen bonds · protein-protein
- A–D · 390 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 381 Ų buried · 2 hydrogen bonds · protein-protein
- A–C · 43 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 cofactor (chromophore).
Compared structures
- 6S67 · Structure of the Fluorescent Protein AausFP1 from Aequorea cf. australis at pH 7.0 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6S67 · PDBe 6S67
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