Research workbench
Crystal structure of aspartate-semialdehyde dehydrogenase from haemophilus influenzae
Analyse Crystal structure of aspartate-semialdehyde dehydrogenase from haemophilus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1NWC
- Type
- protein
- Length
- 712 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Aspartate-semialdehyde dehydrogenase
- EC
- 1.2.1.11
- UniProt
- P44801
- Pockets
- 7 · best druggability 0.61
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) | protein | 356 | 42% helix, 24% strand | P44801 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 364 | 0.61 | 0.77 | 48 | empty |
| 2 | 348 | 0.60 | 0.77 | 43 | empty |
| 3 | 80 | 0.35 | 0.75 | 15 | empty |
| 4 | 52 | 0.32 | 0.77 | 11 | empty |
| 5 | 69 | 0.32 | 0.75 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 3477 Ų buried · 46 hydrogen bonds · protein-protein
Compared structures
- 1NWC · Crystal Structure of Aspartate-Semialdehyde Dehydrogenase from Haemophilus influenzae · the same entry in another collection · chain A against A, TM-score 1.00
- P44801 · AlphaFold monomer V2.0 prediction for aspartate-semialdehyde dehydrogenase (P44801) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P44801
- Elsewhere: RCSB PDB 1NWC · PDBe 1NWC · UniProt P44801
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