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Crystal structure of helicase PIF1 from thermus oshimai in complex with (DT)18

Analyse Crystal structure of helicase PIF1 from thermus oshimai in complex with (DT)18 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6S3P
Type: protein + DNA
Length: 443 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: PIF1 helicase; DNA (5'-D(*TP*TP*TP*TP*TP*TP*TP*T)-3')
UniProt: K7RJ88
Pockets: 6 · best druggability 0.82

Structure

x-ray diffraction · 2 distinct chains · 36% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	PIF1 helicase	protein	436	36% helix, 23% strand	K7RJ88
B	DNA (5'-D(TPTPTPTPTPTPTPT)-3')	dna	7	—	—

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1008	0.82	0.83	101	empty
2	143	0.53	0.81	25	empty
3	71	0.38	0.78	11	empty
4	90	0.37	0.76	22	empty
5	73	0.33	0.75	15	empty

Interfaces

1 interface between chains.

A–B · 887 Å² buried · 18 hydrogen bonds · protein-nucleic

Compared structures

6S3P · Crystal structure of helicase Pif1 from Thermus oshimai in complex with (dT)18 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt K7RJ88
Elsewhere: RCSB PDB 6S3P · PDBe 6S3P · UniProt K7RJ88

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