Research workbench
E. COLI core signaling unit, carrying qqqq receptor mutation
Analyse E. COLI core signaling unit, carrying qqqq receptor mutation in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6S1K
- Type
- protein
- Length
- 2,280 residues
- Chains
- 16
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chemotaxis protein chea; Chew; Methyl-accepting chemotaxis protein I
- EC
- 2.7.13.3
- UniProt
- P07363, P02942
- Pockets
- 20 · best druggability 0.80
Structure
electron microscopy · 3 distinct chains · 43% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Chemotaxis protein chea (EC 2.7.13.3) | protein | 383 | 39% helix, 30% strand | P07363 |
| C, D | Chew | protein | 145 | 19% helix, 50% strand | — |
| E, F, G, H, I, J, K, L, M, N, O, P | Methyl-accepting chemotaxis protein I | protein | 102 | 96% helix, 0% strand | P02942 |
Pockets
20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1195 | 0.80 | 0.81 | 117 | empty |
| 2 | 825 | 0.79 | 0.82 | 86 | empty |
| 3 | 1176 | 0.75 | 0.78 | 116 | empty |
| 4 | 73 | 0.73 | 0.97 | 20 | empty |
| 5 | 1123 | 0.73 | 0.76 | 94 | empty |
Interfaces
27 interfaces between chains.
- M–N · 2160 Ų buried · 4 hydrogen bonds · protein-protein
- O–P · 2099 Ų buried · 4 hydrogen bonds · protein-protein
- G–H · 2095 Ų buried · 7 hydrogen bonds · protein-protein
- E–F · 2043 Ų buried · 3 hydrogen bonds · protein-protein
- I–J · 2023 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6S1K · E. coli Core Signaling Unit, carrying QQQQ receptor mutation · the same entry in another collection · chain P against P, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07363
- Every structure of UniProt P02942
- Elsewhere: RCSB PDB 6S1K · PDBe 6S1K · UniProt P07363 · UniProt P02942
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