Research workbench
Crystal structure of tyrosinase pvdp from pseudomonas aeruginosa bound to copper and phenylthiourea
Analyse Crystal structure of tyrosinase pvdp from pseudomonas aeruginosa bound to… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6RRP
- Type
- protein
- Length
- 909 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pvdp
- UniProt
- Q9I188
- Ligands
- URS, CU
- Pockets
- 11 · best druggability 0.87
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pvdp | protein | 459 | 39% helix, 15% strand | Q9I188 |
| B | Pvdp | protein | 450 | 39% helix, 16% strand | Q9I188 |
Ligands and binding sites
- URS · N-phenylthiourea · ligand · 2 copies · chains A, B
- CU · Copper (II) ion · metal · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1061 | 0.87 | 0.88 | 120 | URS |
| 2 | 216 | 0.55 | 0.78 | 43 | empty |
| 3 | 211 | 0.53 | 0.77 | 39 | empty |
| 4 | 157 | 0.49 | 0.78 | 22 | empty |
| 5 | 149 | 0.47 | 0.77 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 3241 Ų buried · 39 hydrogen bonds · protein-protein
Compared structures
- 6RRP · Crystal structure of tyrosinase PvdP from Pseudomonas aeruginosa bound to copper and… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9I188
- Elsewhere: RCSB PDB 6RRP · PDBe 6RRP · UniProt Q9I188
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