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Crystal structure of the primase fragment of bacteriophage T7 primase- helicase protein
Analyse Crystal structure of the primase fragment of bacteriophage T7 primase- helicase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1NUI
- Type
- protein
- Length
- 481 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA PRIMASE/HELICASE
- EC
- 2.7.7.-
- UniProt
- P03692
- Ligands
- MG, ZN
- Pockets
- 7 · best druggability 0.49
Structure
x-ray diffraction · 2 distinct chains · 29% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA PRIMASE/HELICASE (EC 2.7.7.-) | protein | 242 | 29% helix, 25% strand | P03692 |
| B | DNA PRIMASE/HELICASE (EC 2.7.7.-) | protein | 239 | 30% helix, 26% strand | P03692 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 215 | 0.49 | 0.75 | 20 | empty |
| 2 | 191 | 0.49 | 0.76 | 29 | MG |
| 3 | 130 | 0.46 | 0.78 | 20 | MG |
| 4 | 67 | 0.45 | 0.83 | 14 | empty |
| 5 | 50 | 0.44 | 0.84 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1884 Ų buried · 27 hydrogen bonds · protein-protein
Compared structures
- 1NUI · Crystal Structure of the primase fragment of Bacteriophage T7 primase-helicase protein · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03692
- Elsewhere: RCSB PDB 1NUI · PDBe 1NUI · UniProt P03692
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