Research workbench
Crystal structure of the deah-box ATPase PRP2 in complex with SPP2 and ADP
Analyse Crystal structure of the deah-box ATPase PRP2 in complex with SPP2 and ADP in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6RMB
- Type
- protein
- Length
- 656 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative mRNA splicing factor; Putative pre-mRNA splicing protein
- UniProt
- G0SEG4, G0SFN3
- Ligands
- ADP, MG
- Pockets
- 5 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 43% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Putative mRNA splicing factor | protein | 618 | 44% helix, 19% strand | G0SEG4 |
| D | Putative pre-mRNA splicing protein | protein | 38 | 32% helix, 0% strand | G0SFN3 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1038 | 0.83 | 0.84 | 108 | empty |
| 2 | 377 | 0.68 | 0.81 | 46 | ADP, MG |
| 3 | 94 | 0.59 | 0.87 | 23 | empty |
| 4 | 139 | 0.55 | 0.82 | 22 | empty |
| 5 | 195 | 0.46 | 0.74 | 27 | empty |
Interfaces
1 interface between chains.
- A–D · 1650 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 6RMB · Crystal structure of the DEAH-box ATPase Prp2 in complex with Spp2 and ADP · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0SEG4
- Every structure of UniProt G0SFN3
- Elsewhere: RCSB PDB 6RMB · PDBe 6RMB · UniProt G0SEG4 · UniProt G0SFN3
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