Research workbench
X-ray structure of human relaxin at 1.5 ångströms. comparison to insulin and implications for receptor binding determinants
Analyse X-ray structure of human relaxin at 1.5 ångströms. comparison to insulin and… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6RLX
- Type
- protein
- Length
- 100 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Relaxin, a-chain; Relaxin, B-chain
- UniProt
- P04090
Structure
x-ray diffraction · 3 distinct chains · 66% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Relaxin, a-chain | protein | 24 | 67% helix, 8% strand | P04090 |
| B | Relaxin, B-chain | protein | 27 | 63% helix, 7% strand | P04090 |
| D | Relaxin, B-chain | protein | 25 | 68% helix, 8% strand | P04090 |
Interfaces
6 interfaces between chains.
- A–B · 718 Ų buried · 15 hydrogen bonds · protein-protein
- C–D · 707 Ų buried · 15 hydrogen bonds · protein-protein
- B–C · 242 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 237 Ų buried · 1 hydrogen bond · protein-protein
- A–D · 214 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide, 2 modified (disulfide, cyclization).
Compared structures
- 6RLX · X-ray structure of human relaxin at 1.5 ångströms. comparison to insulin and implications… · the same entry in another collection · chain A against A, TM-score 1.00
- P04090 · AlphaFold monomer V2.0 prediction for prorelaxin H2 (P04090) · a predicted model of the same protein · chain D against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04090
- Elsewhere: RCSB PDB 6RLX · PDBe 6RLX · UniProt P04090
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