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Crystal structure of the murine disabled-1 (DAB1) ptb domain-APOER2 peptide-pi-4,5P2 ternary complex

Analyse Crystal structure of the murine disabled-1 (DAB1) ptb domain-APOER2… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1NU2
Type: protein
Length: 162 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Disabled homolog 1; Peptide derived from murine apolipoprotein E receptor-2
UniProt: P97318
Ligands: I3P

Structure

x-ray diffraction · 2 distinct chains · 33% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Disabled homolog 1	protein	152	35% helix, 33% strand	P97318
B	Peptide derived from murine apolipoprotein E receptor-2	protein	10	0% helix, 20% strand	—

Ligands and binding sites

I3P · D-myo-inositol-1,4,5-triphosphate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 732 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

1NU2 · Crystal structure of the murine Disabled-1 (Dab1) PTB domain-ApoER2 peptide-PI-4,5P2… · the same entry in another collection · chain A against A, TM-score 1.00
P97318 · AlphaFold monomer V2.0 prediction for disabled homolog 1 (P97318) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P97318
Elsewhere: RCSB PDB 1NU2 · PDBe 1NU2 · UniProt P97318

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