Research workbench
Crystal structure of EIS2 form mycobacterium abscessus
Analyse Crystal structure of EIS2 form mycobacterium abscessus in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6RFY
- Type
- protein
- Length
- 2,431 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- EIS2
- EC
- 2.3.1.-
- UniProt
- A0A3A1BNP8
- Ligands
- SO4
- Pockets
- 20 · best druggability 0.85
Structure
x-ray diffraction · 6 distinct chains · 33% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | EIS2 (EC 2.3.1.-) | protein | 405 | 32% helix, 32% strand | A0A3A1BNP8 |
| B | EIS2 (EC 2.3.1.-) | protein | 405 | 33% helix, 32% strand | A0A3A1BNP8 |
| C | EIS2 (EC 2.3.1.-) | protein | 406 | 33% helix, 32% strand | A0A3A1BNP8 |
| D | EIS2 (EC 2.3.1.-) | protein | 407 | 33% helix, 31% strand | A0A3A1BNP8 |
| E | EIS2 (EC 2.3.1.-) | protein | 404 | 32% helix, 32% strand | A0A3A1BNP8 |
| F | EIS2 (EC 2.3.1.-) | protein | 404 | 33% helix, 32% strand | A0A3A1BNP8 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 6 copies · chains A, B, C, D, E, F
- BTB · 2-[bis-(2-hydroxy-ethyl)-amino]-2-hydroxymethyl-propane-1,3-diol · additive · 5 copies · chains A, B, D, E, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 405 | 0.85 | 0.93 | 47 | empty |
| 2 | 419 | 0.84 | 0.92 | 48 | empty |
| 3 | 426 | 0.84 | 0.92 | 49 | empty |
| 4 | 1065 | 0.82 | 0.83 | 109 | BTB, SO4 |
| 5 | 884 | 0.82 | 0.84 | 90 | empty |
Interfaces
12 interfaces between chains.
- A–B · 1951 Ų buried · 20 hydrogen bonds · protein-protein
- C–D · 1923 Ų buried · 21 hydrogen bonds · protein-protein
- E–F · 1922 Ų buried · 24 hydrogen bonds · protein-protein
- A–D · 679 Ų buried · 3 hydrogen bonds · protein-protein
- B–C · 677 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 6RFY · Crystal structure of Eis2 form Mycobacterium abscessus · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A3A1BNP8
- Elsewhere: RCSB PDB 6RFY · PDBe 6RFY · UniProt A0A3A1BNP8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.