Research workbench
PFRH5-binding monoclonal antibody R5.011
Analyse PFRH5-binding monoclonal antibody R5.011 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6RCQ
- Type
- protein
- Length
- 431 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- R5.011 heavy chain; R5.011 light chain
- Pockets
- 3 · best druggability 0.45
Structure
x-ray diffraction · 2 distinct chains · 8% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | R5.011 heavy chain | protein | 222 | 9% helix, 50% strand | — |
| B | R5.011 light chain | protein | 209 | 8% helix, 51% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 201 | 0.45 | 0.74 | 31 | empty |
| 2 | 71 | 0.32 | 0.75 | 15 | empty |
| 3 | 54 | 0.25 | 0.73 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1765 Ų buried · 22 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 6RCQ · PfRH5-binding monoclonal antibody R5.011 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6RCQ · PDBe 6RCQ
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