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Solution structure of the DNA-binding domain of ntrc with three alanine substitutions

Analyse Solution structure of the DNA-binding domain of ntrc with three alanine… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1NTC
Type: protein
Length: 182 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (nitrogen regulation protein (ntrc))
UniProt: P41789
Pockets: 2 · best druggability 0.59

Structure

solution nmr · 1 distinct chain · 56% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Protein (nitrogen regulation protein (ntrc))	protein	91	56% helix, 0% strand	P41789

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	203	0.59	0.81	25	empty
2	56	0.49	0.86	14	empty

Interfaces

1 interface between chains.

A–B · 1327 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

1NTC · Solution structure of the DNA-binding domain of ntrc with three alanine substitutions · the same entry in another collection · chain A against A, TM-score 1.00
P41789 · AlphaFold monomer V2.0 prediction for DNA-binding transcriptional regulator ntrc (P41789) · a predicted model of the same protein · chain A against A, TM-score 0.50

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P41789
Elsewhere: RCSB PDB 1NTC · PDBe 1NTC · UniProt P41789

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