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Full-length bacterial polysaccharide co-polymerase

Analyse Full-length bacterial polysaccharide co-polymerase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6RBG
Type: protein
Length: 2,464 residues
Chains: 8
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Chain length determinant protein
UniProt: P76372
Pockets: 20 · best druggability 0.79

Structure

electron microscopy · 1 distinct chain · 51% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H	Chain length determinant protein	protein	308	51% helix, 8% strand	P76372

Pockets

20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1025	0.79	0.81	117	empty
2	970	0.77	0.80	101	empty
3	859	0.77	0.80	88	empty
4	922	0.77	0.80	97	empty
5	1083	0.75	0.78	93	empty

Interfaces

16 interfaces between chains.

B–C · 2408 Å² buried · 25 hydrogen bonds · protein-protein
F–G · 2405 Å² buried · 25 hydrogen bonds · protein-protein
D–E · 2404 Å² buried · 25 hydrogen bonds · protein-protein
C–D · 2401 Å² buried · 25 hydrogen bonds · protein-protein
G–H · 2400 Å² buried · 25 hydrogen bonds · protein-protein

Compared structures

6RBG · full-length bacterial polysaccharide co-polymerase · the same entry in another collection · chain H against H, TM-score 1.00
P76372 · AlphaFold monomer V2.0 prediction for chain length determinant protein (P76372) · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P76372
Elsewhere: RCSB PDB 6RBG · PDBe 6RBG · UniProt P76372

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