Research workbench
Heterodimeric ABC exporter tmrab in inward-facing wide conformation
Analyse Heterodimeric ABC exporter tmrab in inward-facing wide conformation in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6RAN
- Type
- protein
- Length
- 1,287 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Multidrug resistance ABC transporter ATP-binding and permease protein; Nanobody NB9F10
- UniProt
- Q72J05, Q72J04
- Pockets
- 16 · best druggability 0.83
Structure
electron microscopy · 3 distinct chains · 59% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Multidrug resistance ABC transporter ATP-binding and permease protein | protein | 592 | 65% helix, 9% strand | Q72J05 |
| B | Multidrug resistance ABC transporter ATP-binding and permease protein | protein | 574 | 66% helix, 10% strand | Q72J04 |
| C | Nanobody NB9F10 | protein | 121 | 2% helix, 50% strand | — |
Pockets
16 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1162 | 0.83 | 0.84 | 102 | empty |
| 2 | 405 | 0.62 | 0.77 | 45 | empty |
| 3 | 254 | 0.61 | 0.79 | 32 | empty |
| 4 | 190 | 0.51 | 0.77 | 29 | empty |
| 5 | 121 | 0.49 | 0.79 | 14 | empty |
Interfaces
2 interfaces between chains.
- A–B · 6158 Ų buried · 21 hydrogen bonds · protein-protein
- B–C · 685 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 6RAN · Heterodimeric ABC exporter TmrAB in inward-facing wide conformation · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q72J05
- Every structure of UniProt Q72J04
- Elsewhere: RCSB PDB 6RAN · PDBe 6RAN · UniProt Q72J05 · UniProt Q72J04
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