Research workbench
Heterodimeric ABC exporter tmrab under turnover conditions in asymmetric unlocked return conformation with wider opened intracellular gate
Analyse Heterodimeric ABC exporter tmrab under turnover conditions in asymmetric… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6RAM
- Type
- protein
- Length
- 1,281 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Multidrug resistance ABC transporter ATP-binding and permease protein; Nanobody NB9F10
- UniProt
- Q72J05, Q72J04
- Ligands
- ADP, ATP, MG
- Pockets
- 19 · best druggability 0.84
Structure
electron microscopy · 3 distinct chains · 56% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Multidrug resistance ABC transporter ATP-binding and permease protein | protein | 588 | 61% helix, 9% strand | Q72J05 |
| B | Multidrug resistance ABC transporter ATP-binding and permease protein | protein | 572 | 62% helix, 11% strand | Q72J04 |
| C | Nanobody NB9F10 | protein | 121 | 2% helix, 50% strand | — |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · chains A, B
- ATP · Adenosine-5'-triphosphate · ligand · chains A, B
- MG · Magnesium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
19 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 402 | 0.84 | 0.92 | 55 | empty |
| 2 | 883 | 0.83 | 0.85 | 67 | ATP, MG |
| 3 | 363 | 0.83 | 0.92 | 56 | empty |
| 4 | 244 | 0.78 | 0.92 | 37 | empty |
| 5 | 249 | 0.78 | 0.91 | 34 | empty |
Interfaces
2 interfaces between chains.
- A–B · 7985 Ų buried · 33 hydrogen bonds · protein-protein
- B–C · 703 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 6RAM · Heterodimeric ABC exporter TmrAB under turnover conditions in asymmetric unlocked return… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q72J05
- Every structure of UniProt Q72J04
- Elsewhere: RCSB PDB 6RAM · PDBe 6RAM · UniProt Q72J05 · UniProt Q72J04
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.