Research workbench
Crystal structure of human cln protein 5 (ceroid lipofuscinosis neuronal protein 5)
Analyse Crystal structure of human cln protein 5 (ceroid lipofuscinosis neuronal… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6R99
- Type
- protein
- Length
- 285 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ceroid-lipofuscinosis neuronal protein 5
- UniProt
- A0A024R644
- Ligands
- NAG, BMA
- Pockets
- 4 · best druggability 0.56
Structure
x-ray diffraction · 1 distinct chain · 26% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ceroid-lipofuscinosis neuronal protein 5 | protein | 285 | 26% helix, 33% strand | A0A024R644 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 6 copies · chains A
- BMA · beta-D-mannopyranose · sugar · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 249 | 0.56 | 0.78 | 47 | empty |
| 2 | 88 | 0.42 | 0.78 | 19 | empty |
| 3 | 63 | 0.28 | 0.73 | 14 | empty |
| 4 | 69 | 0.28 | 0.72 | 12 | empty |
Modifications
Observed in the structure: 7 modified, 4 glycan, 2 disulfide (engineered, N-glycosylation, disulfide).
Compared structures
- 6R99 · Crystal Structure of Human CLN protein 5 (Ceroid Lipofuscinosis Neuronal Protein 5) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A024R644
- Elsewhere: RCSB PDB 6R99 · PDBe 6R99 · UniProt A0A024R644
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