Research workbench
Human serum albumin, complexed with sulfasalazine
Analyse Human serum albumin, complexed with sulfasalazine in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6R7S
- Type
- protein
- Length
- 567 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Serum albumin
- UniProt
- P02768
- Ligands
- SAS, SO4
- Pockets
- 9 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 72% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Serum albumin | protein | 567 | 72% helix, 0% strand | P02768 |
Ligands and binding sites
- SAS · 2-hydroxy-(5-([4-(2-pyridinylamino)sulfonyl]phenyl) azo)benzoic acid · ligand · 3 copies · chains A
- SO4 · Sulfate ion · ion · chains A
- DMS · Dimethyl sulfoxide · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1198 | 0.82 | 0.83 | 94 | SO4, SAS |
| 2 | 70 | 0.71 | 0.96 | 20 | empty |
| 3 | 341 | 0.64 | 0.79 | 29 | empty |
| 4 | 138 | 0.58 | 0.83 | 16 | empty |
| 5 | 146 | 0.57 | 0.82 | 20 | SAS |
Modifications
Observed in the structure: 17 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02768
- Elsewhere: RCSB PDB 6R7S · PDBe 6R7S · UniProt P02768
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