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The crystal structure of glycoside hydrolase bglx inactive mutant D286N from P. aeruginosa in complex with glucose
Analyse The crystal structure of glycoside hydrolase bglx inactive mutant D286N from P.… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6R5P
- Type
- protein
- Length
- 1,461 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Periplasmic beta-glucosidase
- UniProt
- Q9I311
- Ligands
- BGC, MG
- Pockets
- 19 · best druggability 0.85
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Periplasmic beta-glucosidase | protein | 729 | 34% helix, 20% strand | Q9I311 |
| A | Periplasmic beta-glucosidase | protein | 732 | 34% helix, 19% strand | Q9I311 |
Ligands and binding sites
- BGC · beta-D-glucopyranose · sugar · 2 copies · chains B, A
- MG · Magnesium ion · metal · 2 copies · chains B, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
19 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 304 | 0.85 | 0.96 | 36 | empty |
| 2 | 93 | 0.76 | 0.98 | 23 | empty |
| 3 | 93 | 0.75 | 0.97 | 23 | empty |
| 4 | 306 | 0.66 | 0.82 | 33 | empty |
| 5 | 265 | 0.64 | 0.81 | 37 | empty |
Interfaces
1 interface between chains.
- B–A · 3338 Ų buried · 68 hydrogen bonds · protein-protein
Compared structures
- 6R5P · The crystal structure of Glycoside Hydrolase BglX inactive mutant D286N from P.… · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9I311
- Elsewhere: RCSB PDB 6R5P · PDBe 6R5P · UniProt Q9I311
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