Research workbench
Influenza a virus (A/NT/60/1968) polymerase dimer of heterotrimer in complex with 5' crna promoter
Analyse Influenza a virus (A/NT/60/1968) polymerase dimer of heterotrimer in complex… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6QX8
- Type
- protein + RNA
- Length
- 2,408 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Polymerase acidic protein; RNA-directed RNA polymerase catalytic subunit; Polymerase…
- EC
- 3.1.-.-, 2.7.7.48
- UniProt
- P03434, P03432, P03429
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 4 distinct chains · 42% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, E | Polymerase acidic protein (EC 3.1.-.-) | protein | 514 | 42% helix, 13% strand | P03434 |
| B, F | RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) | protein | 611 | 43% helix, 9% strand | P03432 |
| C, G | Polymerase basic protein 2 | protein | 67 | 37% helix, 15% strand | P03429 |
| D, H | RNA (5'-R(P*AP*GP*CP*AP*AP*AP*AP*GP*CP*AP*GP*A)-3') | rna | 12 | — | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1111 | 0.84 | 0.85 | 94 | empty |
| 2 | 200 | 0.82 | 0.95 | 52 | empty |
| 3 | 170 | 0.81 | 0.95 | 43 | empty |
| 4 | 90 | 0.78 | 0.99 | 18 | empty |
| 5 | 91 | 0.78 | 0.99 | 19 | empty |
Interfaces
13 interfaces between chains.
- A–B · 7685 Ų buried · 91 hydrogen bonds · protein-protein
- E–F · 7684 Ų buried · 85 hydrogen bonds · protein-protein
- F–G · 1844 Ų buried · 22 hydrogen bonds · protein-protein
- B–C · 1839 Ų buried · 19 hydrogen bonds · protein-protein
- A–D · 1474 Ų buried · 28 hydrogen bonds · protein-nucleic
Compared structures
- 6QX8 · Influenza A virus (A/NT/60/1968) polymerase dimer of heterotrimer in complex with 5' cRNA… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03434
- Every structure of UniProt P03432
- Every structure of UniProt P03429
- Elsewhere: RCSB PDB 6QX8 · PDBe 6QX8 · UniProt P03434 · UniProt P03432 · UniProt P03429
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