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Building a replisome structure from interacting pieces: a sliding clamp complexed with an interaction peptide from DNA polymerase

Analyse Building a replisome structure from interacting pieces: a sliding clamp… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1B77
Type: protein
Length: 684 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (sliding clamp)
UniProt: O80164
Pockets: 5 · best druggability 0.40

Structure

x-ray diffraction · 1 distinct chain · 17% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Protein (sliding clamp)	protein	228	17% helix, 40% strand	O80164

Pockets

5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	113	0.40	0.75	22	empty
2	61	0.37	0.78	13	empty
3	72	0.32	0.74	16	empty
4	57	0.30	0.76	13	empty
5	51	0.28	0.75	12	empty

Interfaces

3 interfaces between chains.

A–B · 509 Å² buried · 10 hydrogen bonds · protein-protein
A–C · 483 Å² buried · 6 hydrogen bonds · protein-protein
B–C · 474 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

1B77 · Building a replisome structure from interacting pieces: a sliding clamp complexed with an… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O80164
Elsewhere: RCSB PDB 1B77 · PDBe 1B77 · UniProt O80164

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