Research workbench
Crystal structure of the C. thermophilum condensin SMC4 ATPase head in complex with the C-terminal domain of BRN1
Analyse Crystal structure of the C. thermophilum condensin SMC4 ATPase head in complex… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6QJ2
- Type
- protein
- Length
- 441 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SMC4; Condensin complex subunit 2
- UniProt
- G0S2G2, G0SBJ6
- Ligands
- SO4
- Pockets
- 6 · best druggability 0.60
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SMC4 | protein | 356 | 33% helix, 28% strand | G0S2G2 |
| B | Condensin complex subunit 2 | protein | 85 | 46% helix, 12% strand | G0SBJ6 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 6 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 67 | 0.60 | 0.90 | 20 | empty |
| 2 | 141 | 0.55 | 0.82 | 22 | empty |
| 3 | 122 | 0.45 | 0.78 | 13 | empty |
| 4 | 78 | 0.38 | 0.77 | 14 | empty |
| 5 | 77 | 0.34 | 0.76 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1307 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 6QJ2 · Crystal structure of the C. thermophilum condensin Smc4 ATPase head in complex with the… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0S2G2
- Every structure of UniProt G0SBJ6
- Elsewhere: RCSB PDB 6QJ2 · PDBe 6QJ2 · UniProt G0S2G2 · UniProt G0SBJ6
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