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Tina-conjugated antiparallel DNA triplex

Analyse Tina-conjugated antiparallel DNA triplex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
6QHI
Type
DNA
Length
22 nucleotides
Chains
3
Method
solution nmr
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
DNA (5'-D(*(DT5)P*CP*CP*TP*CP*CP*(DT3)*(DA5) P*GP*GP*AP*GP*GP*(DA3)*(DT5)P*GP*GP*TP*GP*(TI…

Structure

solution nmr · 3 distinct chains.

ChainMoleculeTypeResiduesSecondary structureUniProt
BDNA (5'-D(*(DT5)P*CP*CP*TP*CP*CP*(DT3)*(DA5) P*GP*GP*AP*GP*GP*(DA3)*(DT5)P*GP*GP*TP*GP*(TIN)P*GP*(DT3))-3')dna7——
CDNA (5'-D(*(DT5)P*CP*CP*TP*CP*CP*(DT3)*(DA5) P*GP*GP*AP*GP*GP*(DA3)*(DT5)P*GP*GP*TP*GP*(TIN)P*GP*(DT3))-3')dna7——
ADNA (5'-D(*(DT5)P*CP*CP*TP*CP*CP*(DT3)*(DA5) P*GP*GP*AP*GP*GP*(DA3)*(DT5)P*GP*GP*TP*GP*(TIN)P*GP*(DT3))-3')dna8——

Interfaces

3 interfaces between chains.

  • C–A · 444 Ų buried · 24 hydrogen bonds · nucleic-nucleic
  • B–C · 328 Ų buried · 35 hydrogen bonds · nucleic-nucleic
  • B–A · 233 Ų buried · 0 hydrogen bonds · nucleic-nucleic

Modifications

Observed in the structure: 1 modified (nucleotide modification).

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