Research workbench
Structure of an E.COLI expressed anti-MCL1 scfv
Analyse Structure of an E.COLI expressed anti-MCL1 scfv in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6QF6
- Type
- protein
- Length
- 909 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- E.COLI expressed scfv
- Pockets
- 7 · best druggability 0.70
Structure
x-ray diffraction · 3 distinct chains · 4% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E.COLI expressed scfv | protein | 226 | 3% helix, 47% strand | — |
| B, D | E.COLI expressed scfv | protein | 228 | 5% helix, 50% strand | — |
| C | E.COLI expressed scfv | protein | 227 | 3% helix, 51% strand | — |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 717 | 0.70 | 0.77 | 68 | empty |
| 2 | 189 | 0.53 | 0.78 | 23 | empty |
| 3 | 165 | 0.45 | 0.75 | 21 | empty |
| 4 | 99 | 0.43 | 0.79 | 19 | empty |
| 5 | 136 | 0.42 | 0.75 | 16 | empty |
Interfaces
5 interfaces between chains.
- A–B · 508 Ų buried · 13 hydrogen bonds · protein-protein
- A–C · 296 Ų buried · 4 hydrogen bonds · protein-protein
- C–D · 163 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 98 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 51 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 6QF6 · Structure of an E.coli expressed anti-Mcl1 scFv · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6QF6 · PDBe 6QF6
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